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KMID : 0364820110470010163
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Korean Journal of Microbiology
2011 Volume.47 No. 1 p.163 ~ p.166
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Action Pattern of Anti-Yeast Substance Originated from Rahnella aquatilis Strain AY2000
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Park Hae-Ji
Kang Min-Jung
Lee Jong-Hwan
Kim Kwang-Hyeon
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Abstract
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For reduction of side effects by anti-fungal agents, a less toxic anti-fungal substance or a synergistic substance with a new mechanism is needed. The anti-yeast substance (AYS) originated from Rahnella aquatilis strain AY2000 is like to be a heterogeneous protein. The AYS inhibited the growth of Candida albicans in culture broth, and AYS-treated cells were arrested in each phase during cell cycle. Among AYS-treated cells, the population of the cells belonging to sub-G1 phase was not increased during cell cycle. Therefore, AYS has rather yeaststatic than yeastcidal effect to C. albicans. Moreover, with combination of itraconazole or fluconazole, AYS had a synergistic anti-yeast activity against Saccharomyces erevisiae based on the analysis of fractional inhibitory concentration index.
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KEYWORD
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Rahnella aquatilis, anti-fungal substance, anti-yeast, cell cycle, synergistic activity
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